Bromine → HCID 91458778, compound

Participants

Reaction Steps

A 0° C. solution of Example 27A (350 mg, 0.98 mmol) in DMF (10 mL) was treated with Br2 (0.102 mL, 1.98 mmol), warmed to room temperature, and stirred for 1 hour. The reaction was cooled to 0° C., quenched with 1:1 10% NaHSO3/saturated NaHCO3, and extracted three times with ethyl acetate. The combined extracts were washed with water and brine, dried (Na2SO4), filtered, and concentrated to provide 400 mg (93%) of the desired product. MS (ESI(−)) m/e 433, 435 (M−H)−.

Provenance & Evidence