Pyridine → HCID 68519721, compound

Participants

Reaction Steps

A 0° C. solution of Example 30 (126 mg, 0.3 mmol) in DMF (2 mL) at room temperature was treated with pyridine (0.121 mL, 1.5 mmol) and 3-methylphenylisocyanate (0.038 mL, 0.3 mmol) and stirred overnight. The reaction mixture was poured into ice water and filtered. The filter cake was recrystallized from ethyl acetate/hexanes to provide 87 mg (80% yield) of the desired product. MS (ESI(+)) m/e 361 (M+H)+; 1H NMR (DMSO-d6) δ 9.00 (s, 1H), 8.69 (s, 1H), 8.42 (s, 1H), 7.68 (q, J=15, 8.7 Hz, 4H), 7.10-7.40 (m, 3H), 6.82 (d, J=7.2 Hz, 1H), 2.28 (s, 3H).

Provenance & Evidence