Dimethylformamide → HCID 68679805, compound

Participants

Reaction Steps

The solid supported 2-bromostyrylquinazoline (3) (0.054 mmol, 0.54 mmol/g), phenylboronic acid (0.5 mmol), Pd(PPh3)4 (20 mg), triethylamine (20 ml) and 2 ml DMF are placed in a fritted polypropylene tube. The mixture is agitated at 80° for 24 h. After cooling to rt, the mixture is customary worked up for solid phase reactions. The solid-supported 2-(2-biphenyl-4-yl-vinyl)-quinazoline and 2 ml of a mixture of H2O, TFA and dichloromethane (1:49:50) is placed in a fritted polypropylene tube. The contents are shaken for 2 h at rt. The suspension is filtered and the resin is washed with dichloromethane (1 ml) and methanol (1 ml) respectively. Evaporation of the combined filtrates give (3-aminomethyl-cyclohexylmethyl)-[2-(2-biphenyl-4-yl-vinyl)-quinazolin-4-yl]-amine;

Provenance & Evidence