Sodium Azide → HCID 58972934, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of bis-tert-butoxycarbonyl-(7-bromomethyl-isoquinolin-1-yl)amine (280 mg, 0.64 mmol) and NaN3 (300 mg, 4.6 mmol) in 3 mL of DMSO was heated at 85° C. for 1 h. Then the solution was cooled down to rt, diluted with water and extracted with 50% EtOAc in hexane. The combined organic layers were washed with water. Removal of solvents furnished the crude product as a yellow oil (200 mg).

Provenance & Evidence