HCID 68682176, compound → HCID 57951098, compound

Participants

Reaction Steps

2-(4-Bromo-3,5-difluorophenyl)-2-ethyl-1,3-dioxolane (1.20 g) was dissolved in 1 N hydrochloric acid/tetrahydrofuran/acetic acid (1/1/1, 30 ml). The reaction liquid was stirred overnight with heating under reflux, then diluted with ethyl acetate, and washed with aqueous saturated sodium hydrogencarbonate solution. The organic layer was dried with anhydrous sodium sulfate, then the solvent was evaporated off, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1) to obtain the entitled compound (806 mg) as a pale yellow oil.

Provenance & Evidence