3,5-Difluoroaniline → HCID 68684330, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-oxo-2-(2-oxopropyl)pentanoate (200 mg) and 3,5-difluoroaniline (380 mg) were dissolved in acetic acid (10 mL), and stirred at 80° C. for 2.5 hours. The reaction liquid was cooled to room temperature, then the solvent was evaporated off, the residue was diluted with chloroform, and washed with aqueous saturated sodium hydrogencarbonate solution. The extract was washed with saturated saline water, then dried with anhydrous sodium sulfate, then the solvent was evaporated off, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1) to obtain the entitled compound (287 mg) as a pale yellow oil.

Provenance & Evidence