Triethylamine → HCID 24852107, compound

Participants

Reaction Steps

Treat a solution of (R)-3-(3,5-Dichloro-4′-fluoro-biphenyl-4-ylmethyl)-1-piperidin-4-yl-pyrrolidin-2-one trifluoroacetic acid (Preparation 29) (0.10 g, 0.19 mmol) in CH2Cl2 (3 mL) with methyl isocyanate (21 mg, 0.36 mmol) and triethylamine (0.07 mL, 0.48 mmol). Stir the reaction overnight at room temperature. Quench the reaction with 1N HCl and extract with Et2O. Wash the organic with brine, dry over MgSO4, and filter. Purify the crude by silica gel column chromatography using Hexanes:EtOAc to elute pure product. Remove the solvent to afford 0.097 g (84%) of product. MS (m/e): 478 (M+1).

Provenance & Evidence