Potassium Carbonate → HCID 66671794, compound

Participants

Reaction Steps

A solution of (R)-3-[3,5-Dichloro-4′-(4-trifluoromethyl-piperidine-1-carbonyl)-biphenyl-4-ylmethyl]-1-piperidin-4-yl-pyrrolidin-2-one trifluoroacetic acid (Preparation 30) (112 mg, 0.16 mmol) and potassium carbonate (40 mg, 0.32 mmol) in Acetone (5 mL) is treated with Trimethylsilyl-isocyanate (30 mg, 0.24 mmol). The reaction is stirred overnight at room temperature. The reaction is quenched with 1N HCl and extracted with Et2O. The organic is washed with brine, dried over MgSO4, and filtered. The crude is purified by silica gel column chromatography using Hexanes:EtOAc to elute pure product. The solvent is removed to afford 0.038 g (38%) of product. MS (m/e): 626 (M+1).

Provenance & Evidence