反应详情

2,6-diamino-nicotinic acid ethyl ester (2 g, 11 mmol) described in Production Example 1-1-3 was dissolved in ethanol (15 mL) followed by the addition of 1 N aqueous sodium hydroxide solution (15 mL) and stirring for 2 hours while heating under reflux. After allowing the reaction mixture to return to room temperature, the ethanol was distilled off under a reduced pressure and the residue was cooled with ice and neutralized with 1 N hydrochloric acid. After filtering the precipitated solid and washing with water, the solid was dried to obtain the title compound (1.72 g, 11 mmol, quantitative).

1. temperaturewhile heating
2. temperatureunder reflux
3. customto return to room temperature
4. distillationthe ethanol was distilled off under a reduced pressure
5. temperaturethe residue was cooled with ice and neutralized with 1 N hydrochloric acid
6. filtrationAfter filtering the precipitated solid
7. washwashing with water
8. customthe solid was dried