反应详情

To a tetrahydrofuran (5 mL) solution of 6-phenoxy-benzofuran-2-carboxylic acid ethyl ester (251 mg, 889 μmol) described in Production Example 49-1-1 was added lithium aluminum hydride (135 mg, 3.56 mmol) at 0° C., which was stirred at room temperature for 2 hours. To the reaction solution were added water (135 μL), 5 N aqueous sodium hydroxide solution (135 μL) and water (405 μL) at 0° C., followed by filtering through celite. The filtrate was concentrated under a reduced pressure and the residue was purified by NH silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain the title compound (177 mg, 83%) as a colorless oil.

1. filtrationby filtering through celite
2. concentrationThe filtrate was concentrated under a reduced pressure
3. customthe residue was purified by NH silica gel column chromatography (hexane:ethyl acetate=1:1)