Water → HCID 57608234, compound

Participants

Reaction Steps

To a trifluoroacetic acid solvent of 2-amino-N-(6-benzyloxy-benzofuran-2-ylmethyl)-nicotinamide (323 mg, 865 mmol) described in Example 58 at 0° C., which was stirred at room temperature for 3 hours. Sodium bicarbonate and water were added to the reaction solution at 0° C. followed by extraction with ethyl acetate. The organic layer was washed with sat. NaCl followed by drying by adding anhydrous magnesium sulfate and filtering. The filtrate was concentrated under a reduced pressure and the resulting residue was purified by NH silica gel column chromatography (ethyl acetate:methanol=10:1) to obtain the title compound (219 mg, 89%) as a white solid.

Provenance & Evidence