反应详情

温度

0 °C

To a dichloromethane (10 mL) solution of 6-methoxy-1H-indole-2-carboxylic acid methyl ester (500 mg, 2.44 mmol) was added boron tribromide (12.2 mL, 12.2 mmol) at −78° C., which was stirred for 50 minutes at 0° C. under nitrogen atmosphere. To the reaction solution was added water at 0° C. followed by extraction with ethyl acetate. The organic layer was washed with sat. NaCl followed by drying over anhydrous magnesium sulfate and filtering. The filtrate was concentrated under a reduced pressure and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1) to obtain the title compound (395 mg, 85%) as a white solid.

1. extractionfollowed by extraction with ethyl acetate
2. washThe organic layer was washed with sat. NaCl
3. dry with materialby drying over anhydrous magnesium sulfate
4. filtrationfiltering
5. concentrationThe filtrate was concentrated under a reduced pressure
6. customthe residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1)