Ammonia methanol → HCID 57608214, compound

Participants

Reaction Steps

To an ammonia-methanol (5 mL) solution of 6-cyclopropylmethoxy-1H-indole-2-carbaldehyde (144 mg, 669 μmol) described in Production Example 73-1-4 was added Raney nickel, which was stirred at room temperature for 8 hours under hydrogen atmosphere. The reaction mixture was filtered through Celite and the filtrate was concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate:methanol=10:1) to obtain the title compound (91 mg, 63%) as a pale brown oil.

Provenance & Evidence