Morpholine → HCID 59553258, compound

HRID 1171269Notes

Reaction equation

HRID 1171269 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[CH3:30])[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[CH:10][CH:9]=1)=[O:6].[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[CH3:30][C:29]1[CH:28]=[CH:27][C:4]([C:5]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([O:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[CH:10][CH:9]=2)=[O:6])=[CH:3][C:2]=1[N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 59553358HCID 59553358, compound

Product 1

HCID 59553258HCID 59553258, compound

Procedure

Compound is formed by reacting 3-bromo-4-methyl-N-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-benzamide with morpholine under conditions described in general procedure B. 1H NMR (300 MHz, CDCl3) δ 8.32 (m, 1H), 7.98 (broad s, 1H), 7.86 (m, 1H), 7.74 (m, 2H), 7.53 (m, 3H), 7.32 (m, 1H), 6.87 (t, 1H, J=7.5), 4.34 (m, 2H), 3.88 (m, 4H), 3.77 (m, 4H), 2.97 (m, 6H), 2.68 (m, 4H), 2.42 (d, 3H, J=5.7). MS: 476.2 (M+1).

Workup

  1. customCompound is formed

Sources & evidence

ORD record
ord-60e73fb28b594df7994536e76d15e9e2
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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