Cyclopentylamine → HCID 59553207, compound

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Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide (0.1 mmol) and cyclopentylamine (10 mmol) according to conditions described in general procedure C. Compound is produced (25 mg) as a light yellow solid; Mp: 119-120° C.; 1H NMR (300 MHz, CDCl3) δ 1.23-1.38 (m, 4H), 1.53-1.88 (m, 4H), 3.22-3.25 (m, 4H), 3.84-3.86 (m, 4H), 4.08-4.15 (m, 1H), 5.06 (bs, 1H), 6.07 (bs, 1H), 6.76 (d, J=11.7 Hz, 1H), 7.07 (d, J=8.4 Hz, 1H), 7.25-7.31 (m, 2H), 7.48-7.58 (m, 2H), 7.85-7.98 (m, 3H), 8.14 (s, 1H), 8.25 (s, 1H); MS: 528 (M+1).

Provenance & Evidence