2,2-Dimethoxyethylmethylamine → N-[4-({2-[(2,2-Dimethoxyethyl)(methyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-3-fluoro-5-morpholin-4-ylbenzamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2,2-Dimethoxyethylmethylamine	HCID 8503	—
Edukt	3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide	HCID 59553095	—
Produkt	N-[4-({2-[(2,2-Dimethoxyethyl)(methyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-3-fluoro-5-morpholin-4-ylbenzamide	HCID 59553499	—

Reaktionsschritte

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and (2,2-dimethoxy-ethyl)-methylamine according to conditions described in general procedure C. Mp: 92-94° C.; 1H NMR (400 MHz, DMSO-d6) δ 2.84-3.6 (m, 11 H), 3.28 (m, 4 H), 3.77 (m, 4 H), 4.5 (s, 1 H), 6.26-6.24 (m, 1 H), 7.04 (d, J=12.0 Hz, 1 H), 7.26 (d, J=9.1Hz, 1 H), 7.47-7.65 (m, 5 H), 7.82 (m, 1 H), 7.99-8.01 (m, 1 H), 8.29 (m, 1 H), 10.45 (s, 1 H).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07829560B2
Quelldatensatz	uspto-grants-2010_11
ORD ID	ord-5241fcf2287e4106b7a14035953e6b87
Quellennotiz	uspto-grants-2010_11