Cyclopropylamine → HCID 59553185, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl) pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and cyclopropylamine according to conditions described in general procedure C. Mp: 118-120° C.; 1H NMR (400 MHz, CDCl3) δ 0.42-0.49 (m, 2 H), 0.70 (d, J=5.6 Hz, 2 H), 2.65 (s, 1 H), 3.25 (t, J=4.0 Hz, 4 H), 3.86 (t, J=4.8 Hz, 4H), 5.25 (s, 1 H), 6.15 (d, J=4.8 Hz, 1 H), 6.78 (d, J=11.6 Hz, 1 H), 7.06 (d, J=8.4 Hz, 2 H), 7.26-7.31 (m, 2 H), 7.49-7.57 (m, 2 H), 7.89 (d, J=8.0 Hz, 1 H), 7.96 (d, J=8.0 Hz, 1 H), 8.15 (s, 1 H), 8.20 (d, J=4.4 Hz, 1 H).

Provenance & Evidence