N-Methylisopropylamine → HCID 59553064, compound

HRID 1171284Notes

Reaction equation

HRID 1171284 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH:38]([NH:41][CH3:42])([CH3:40])[CH3:39]>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:41]([CH:38]([CH3:40])[CH3:39])[CH3:42])[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 78485N-MethylisopropylamineHCID 595530953-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide

Product 1

HCID 59553064HCID 59553064, compound

Procedure

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and N-isopropylmethylamine according to conditions described in general procedure C. Mp: 94-96° C.; 1H NMR (400 MHz, CDCl3) δ 1.06-1.14 (m, 6 H), 2.84 (s, 3 H), 3.25 (t, J=4.0 Hz, 4 H), 3.87 (t, J=4.8 Hz, 4H), 5.95 (d, J=5.2 Hz, 1 H), 6.78 (d, J=11.2 Hz, 1 H), 7.07 (d, J=8.0 Hz, 1H), 7.31 (d, J=8.0 Hz, 1 H), 7.49-7.59 (m, 3 H), 7.89 (d, J=8.8 Hz, 1 H), 7.96 (d, J=7.6 Hz, 1H), 8.01 (d, J=8.0 Hz, 1 H), 8.14-8.17 (m, 2 H).

Sources & evidence

ORD record
ord-5911e3c430884151a56a08fa11ea2cd3
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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