4-(N-Boc-amino)piperidine → HCID 59553128, compound

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Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and piperidin-4-yl-carbamic acid t-butyl ester according to conditions described in general procedure C. Mp: 214-216° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.33-1.41 (m, 14 H), 2.47-3.41 (m, 4H), 3.25-3.28 (m, 4H), 3.75-3.78 (m, 4 H), 4.20 (s, 1 H), 6.20 (d, J=5.5 Hz, 1H), 6.77-6.79 (m, 1 H), 7.00-7.05 (m, 1H), 7.18-7.26 (m, 1H), 7.38-7.63 (m, 5H), 7.85 (d, J=9.2 Hz, 1H), 8.00 (d, J=8.4 Hz, 1H), 8.26 (d, J=5.5 Hz, 1H), 10.47 (s, 1H).

Provenance & Evidence