Piperazin-2-one → HCID 59553389, compound

HRID 1171288Notes

Reaction equation

HRID 1171288 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[NH:38]1[CH2:43][CH2:42][NH:41][CH2:40][C:39]1=[O:44]>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:41]3[CH2:42][CH2:43][NH:38][C:39](=[O:44])[CH2:40]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 595530953-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide

Product 1

HCID 59553389HCID 59553389, compound

Procedure

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and piperazin-2-one according to conditions described in general procedure C. Mp: 108-110° C.; 1H NMR (400 MHz, DMSO-d6) δ 3.14-3.35 (m, 8 H), 3.73-3.78 (m, 6 H), 6.37 (d, J=5.5 Hz, 1 H), 7.03-7.06 (m, 2 H), 7.26 (d, J=8.5 Hz, 1 H), 7.44-7.63 (m, 4 H), 7.84-7.86 (m, 1 H), 8.00-8.04 (m, 2H), 8.35 (d, J=5.1Hz, 1 H), 10.51 (s, 1 H).

Sources & evidence

ORD record
ord-f293b641953946a694d779e05560e600
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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