1-(1,3-Dioxolan-2-yl)methanamine → N-[4-({2-[(1,3-dioxolan-2-ylmethyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-3-fluoro-5-morpholin-4-ylbenzamide

Participants

Role	Name	HCID	Charge
Reactant	1-(1,3-Dioxolan-2-yl)methanamine	HCID 10855394	—
Reactant	3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide	HCID 59553095	—
Product	N-[4-({2-[(1,3-dioxolan-2-ylmethyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-3-fluoro-5-morpholin-4-ylbenzamide	HCID 59553243	—

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and C-[1,3]dioxolan-2-yl-methylamine according to conditions described in general procedure C. Mp: 122-124° C.; 1H NMR (400 MHz, DMSO-d6) δ 3.25-3.30 (m, 6 H), 3.73-3.83 (m, 8 H), 4.19 (bs, 1 H), 6.36 (bs, 1 H), 7.04 (d, J=12.0 Hz, 1 H), 7.26-7.31 (m, 2 H), 7.38-7.61 (m, 5 H), 7.83 (d, J=8.8 Hz, 1 H), 7.99 (d, J=9.2 Hz, 1 H), 8.20 (s, 1 H), 10.46 (s, 1 H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07829560B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-b8fd633489254cf7b1dd5b16e93dc8ec
Source note	uspto-grants-2010_11