(3R)-(+)-3-(Dimethylamino)pyrrolidine → HCID 59553338, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and (R)—N,N-dimethylpyrrolidin-3-amine according to conditions described in general procedure C. Mp: 115-117° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.70-2.10 (m, 2 H), 2.13 (s, 6 H), 2.68-3.10 (m, 5 H), 3.25 (t, J=4.4 Hz, 4 H), 3.74 (t, J=4.8 Hz, 4 H), 6.15 (bd, 1 H), 7.04 (d, J=12.0 Hz, 1 H), 7.24 (d, J=8.4 Hz, 1 H), 7.40-7.61 (m, 5 H), 7.84 (d, J=8.0 Hz, 1 H), 7.98 (d, J=8.4 Hz, 1 H), 8.22 (d, J=5.5 Hz, 1 H), 10.45 (s, 1 H).

Provenance & Evidence