Cyclobutylamine → HCID 59553433, compound

Participants

Role	Name	HCID	Charge
Reactant	Cyclobutylamine	HCID 75645	—
Reactant	3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide	HCID 59553095	—
Product	HCID 59553433	HCID 59553433	—

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and cyclobutylamine according to conditions described in general procedure C. Mp: 110-112° C.; 1H NMR (400 MHz, CDCl3) δ 1.63 (s, 2 H), 1.73-1.80 (m, 2 H), 2.42 (s, 2 H), 3.19-3.29 (m, 4 H), 3.79-3.92 (m, 4 H), 4.30 (s, 1 H), 5.27 (s, 1 H), 6.08 (s, 1 H), 6.75-6.78 (m, 1 H), 7.05 (d, J=7.6 Hz, 1 H), 7.24-7.26 m, 1 H), 7.32 (s, 1 H), 7.47-7.57 (m, 2 H), 7.88-8.02 (m, 3 H), 8.16 (m, 1 H), 8.25 (s, 1 H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07829560B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-43d5a53e1cb448f5acf76d66b2172c28
Source note	uspto-grants-2010_11