Isobutylamine → HCID 59553398, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and isobutylamine according to conditions described in general procedure C. Mp: 96-97° C.; 1H NMR (400 MHz, DMSO-d6) δ 0.60-0.80 (m, 6 H), 1.80 (m, 1 H), 2.89 (s, 2 H), 3.26 (t, J=4.8 Hz, 4 H), 3.77 (t, J=5.2 Hz, 4 H), 6.20-6.40 (bd, 1 H), 7.03-7.07 (m, 1 H), 7.22 (s, 1 H), 7.27 (d, J=8.4 Hz, 1 H), 7.40 (d, J=8.0 Hz, 1 H), 7.47 (s, 1 H), 7.55-7.62 (m, 3 H), 7.81-7.83 (m, 1H), 8.00 (d, J=8.4 Hz, 1 H), 8.21 (s, 1 H), 10.45 (s, 1 H).

Provenance & Evidence