3-Thiophenamine, tetrahydro-, 1,1-dioxide → N-[4-({2-[(1,1-Dioxidotetrahydro-3-thienyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-3-fluoro-5-morpholin-4-ylbenzamide

Participants

Role	Name	HCID	Charge
Reactant	3-Thiophenamine, tetrahydro-, 1,1-dioxide	HCID 22807	—
Reactant	3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide	HCID 59553095	—
Product	N-[4-({2-[(1,1-Dioxidotetrahydro-3-thienyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-3-fluoro-5-morpholin-4-ylbenzamide	HCID 59553196	—

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and 1,1-Dioxo-tetrahydro-1λ6-thiophen-3-ylamine according to conditions described in general procedure C. Mp: 150-151° C.; 1H NMR (400 MHz, DMSO-d6) δ 2.04 (s, 2 H), 2.30 (s, 1 H), 2.88 (s, 2 H), 3.07 (s, 2 H), 3.26 (t, J=4.4 Hz, 4 H), 3.77 (t, J=4.8 Hz, 4 H), 4.56 (s, 1 H), 6.49 (s, 1 H), 7.04 (d, J=12.4 Hz, 1 H), 7.26 (d, J=8.8 Hz, 1 H), 7.43 (d, J=8.0 Hz, 1 H), 7.47 (s, 1 H), 7.56-7.61 (m, 3 H), 7.81-7.84 (m, 1 H), 7.99 (d, J=7.6 Hz, 1 H), 8.30 (d, J=4.0 Hz, 1 H), 10.46 (s, 1 H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07829560B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-3bc902561a4a46fb94b4072fff4cec68
Source note	uspto-grants-2010_11