1,4-Dioxa-8-azaspiro(4.5)decane → N-(4-{[2-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)pyrimidin-4-yl]oxy}-1-naphthyl)-3-fluoro-5-morpholin-4-ylbenzamide

Participants

Role	Name	HCID	Charge
Reactant	1,4-Dioxa-8-azaspiro(4.5)decane	HCID 67435	—
Reactant	3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide	HCID 59553095	—
Product	N-(4-{[2-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)pyrimidin-4-yl]oxy}-1-naphthyl)-3-fluoro-5-morpholin-4-ylbenzamide	HCID 59553139	—

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and 1,4-dioxa-8-aza-spiro[4.5]decane according to conditions described in general procedure C. Mp: 115-117° C.; 1H NMR (400 MHz, CDCl3) δ 1.64 (t, J=5.0 Hz, 4 H), 3.26 (t, J=4.3 Hz, 4 H), 3.77 (s, 4 H), 3.88 (t, J=4.7 Hz, 4 H), 3.96 (s, 4 H), 5.98-5.99 (m, 1H), 6.77 (d, J=11.7 Hz, 1 H), 7.07 (d, J=7.8 Hz, 1 H), 7.32-7.34 (m, 2 H), 7.50-7.60 (m, 3 H), 7.90 (d, J=8.2 Hz, 1 H), 8.00 (d, J=8.6 Hz, 1H), 8.10 (s, 2 H), 8.15-8.17 (m, 1 H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07829560B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-cd84e3bcb06d491e9c02841e5ba1a211
Source note	uspto-grants-2010_11