Imidazole → HCID 59553086, compound

HRID 1171315Notes

Reaction equation

HRID 1171315 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[NH:38]1[CH:42]=[CH:41][N:40]=[CH:39]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:38]3[CH:42]=[CH:41][N:40]=[CH:39]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 795ImidazoleHCID 595530953-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide

Product 1

HCID 59553086HCID 59553086, compound

Procedure

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and imidazole according to conditions described in general procedure C. Mp: 153-154° C.; 1H NMR (400 MHz, CDCl3) δ 3.29 (s, 4 H), 3.89 (s, 4 H), 6.79-6.85 (m, 2 H), 7.01 (d, J=1.5 Hz, 1 H), 7.12 (d, J=8.2 Hz, 1 H), 7.35 (d, J=2.7 Hz, 1 H), 7.38 (d, J=2.3 Hz, 1 H), 7.53-7.64 (m, 3 H), 7.91-7.93 (m, 1 H), 7.97 (d, J=7.4 Hz, 1 H), 8.05 (d, J=8.2 Hz, 1 H), 8.25-8.27 (m, 2 H), 8.53-8.56 (m, 1 H).

Sources & evidence

ORD record
ord-7ce578d724c84aad89727305c082dab3
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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