Cyclobutylamine → N-(4-{[2-(Cyclobutylamino)pyrimidin-4-yl]oxy}-1-naphthyl)-3-fluoro-5-piperidin-1-ylbenzamide

Participants

Role	Name	HCID	Charge
Reactant	Cyclobutylamine	HCID 75645	—
Reactant	3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide	HCID 66737969	—
Product	N-(4-{[2-(Cyclobutylamino)pyrimidin-4-yl]oxy}-1-naphthyl)-3-fluoro-5-piperidin-1-ylbenzamide	HCID 59553208	—

Reaction Steps

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and cyclobutylamine according to conditions described in general procedure C. Mp: 112-114° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.58-1.61 (m, 7 H), 1.80 (bs, 2 H), 2.10 (s, 1 H), 3.27-3.28 (m, 5 H), 6.32 (s, 1 H), 6.98 (d, 1 H), 7.15 (d, 1 H), 7.36-7.54 (m, 3 H), 7.57-7.62 (m, 3 H), 7.80 (d, 1 H), 7.95 (d, 1 H), 8.20 (s, 1 H), 10.41 (s, 1 H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07829560B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-a1124b849ddb4dd6b8f6185bf4219148
Source note	uspto-grants-2010_11