4-Amino-1-methylpiperidine → HCID 59553309, compound

HRID 1171337Notes

Reaction equation

HRID 1171337 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[NH2:38][CH:39]1[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH:38][CH:39]3[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 667379693-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide

Product 1

HCID 59553309HCID 59553309, compound

Procedure

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 4-amino-N-methylpiperidine according to conditions described in general procedure C. 1H NMR (400 MHz, DMSO-d6) δ 1.41-1.84 (m, 10 H), 2.09 (s, 3 H), 2.54-3.03 (m, 4 H), 2.92 (s, 4 H), 3.63 (s, 1 H), 6.30 (s, 1 H), 6.94-6.98 (m, 2 H), 7.15 (d, J=8.8 Hz, 1 H), 7.37 (d, J=8.0 Hz, 1 H), 7.43 (s, 1 H), 7.51-7.61 (m, 3 H), 7.80 (d, J=8.8 Hz, 1 H), 7.97 (d, J=8.4 Hz, 1 H), 8.20 (s, 1 H), 10.42 (s, 1 H).

Sources & evidence

ORD record
ord-7af0b60423e84edb80304360512a12ed
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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