1-Pyrrolidineethanamine → HCID 59553272, compound

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Reaction Steps

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 2-pyrrolidin-1-yl-ethylamine according to conditions described in general procedure C. Mp: 92-94° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.58 (m, 10 H), 2.20-2.47 (m, 6 H), 2.91 (bs, 2 H), 3.27 (s, 4 H), 6.20-6.32 (m, 1 H), 6.94-6.98 (m, 2 H), 7.15 (d, J=8.4 Hz, 1 H), 7.37 (d, J=8.0 Hz, 1 H), 7.43 (s, 1 H), 7.51-7.61 (m, 3 H), 7.78-7.80 (m, 1 H), 7.96 (d, J=7.3 Hz, 1 H), 8.21 (s 1 H), 10.40 (s, 1 H).

Provenance & Evidence