tert-Butyl piperazine-1-carboxylate → tert-Butyl-4-[4-({4-[(3-fluoro-5-piperidin-1-ylbenzoyl)amino]-1-naphthyl}oxy)pyrimidin-2-yl]piperazine-1-carboxylate

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Reaction Steps

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and N-(tert-butoxy carbonyl)piperazine according to conditions described in general procedure C. Mp: 175-177° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.36 (s, 9 H), 1.58-1.59 (m, 6 H), 3.24-3.31 (m, 8 H), 3.47 (s, 4 H), 6.22 (d, J=5.5 Hz, 1H), 6.96 (d, J=12.4 Hz, 1 H), 7.15 (d, J=9.1Hz, 1 H), 7.41 (d, J=8.0 Hz, 1 H), 7.47 (s, 1 H), 7.50-7.62 (m, 3 H), 7.82-7.84 (m, 1 H), 7.98 (d, J=7.7 Hz, 1 H), 8.27 (d, J=5.5 Hz, 1 H), 10.43 (s, 1 H).

Provenance & Evidence