3-(Dimethylamino)pyrrolidine → HCID 59553299, compound

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Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and dimethyl-pyrrolidin-3-yl-amine according to conditions described in general procedure C. Mp: 108-110° C.; 1H NMR (400 MHz, CDCl3) δ 1.61-1.77 (m, 6 H), 1.80-2.2.15 (m, 2 H), 2.17-2.27 (m, 6 H), 2.72 (bs, 1 H), 3.20-3.91 (m, 4 H), 3.25-3.27 (m, 4 H), 5.82-5.84 (bd, 1 H), 6.73-6.77 (m, 1 H), 6.97 (d, J=8.0 Hz, 1 H), 7.29-7.34 (m, 2 H), 7.46-7.64 (m, 2 H), 7.88-8.00 (m, 3 H), 8.13-8.20 (m, 2 H), 8.22 (d, J=5.5 Hz, 1 H).

Provenance & Evidence