2-(Methylsulfonyl)ethanamine → HCID 59553462, compound

HRID 1171348Notes

Reaction equation

HRID 1171348 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH3:38][S:39]([CH2:42][CH2:43][NH2:44])(=[O:41])=[O:40]>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH:44][CH2:43][CH2:42][S:39]([CH3:38])(=[O:41])=[O:40])[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 667379693-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide

Product 1

HCID 59553462HCID 59553462, compound

Procedure

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 2-methanesulfonylethylamine according to conditions described in general procedure C. Mp: 102-104° C.; 1H NMR (400 MHz, CDCl3) δ 1.62-1.71 (m, 6 H), 2.54-2.64 (m, 5 H), 3.27 (t, J=5.5 Hz, 4 H), 3.50 (s, 2 H), 5.66 (bs, 1 H), 6.31 (d, J=5.5 Hz, 1 H), 6.76 (d, J=11.1 Hz, 1 H), 6.98 (d, J=8.5 Hz, 1 H), 7.23 (d, J=8.0 Hz, 1 H), 7.30 (s, 1 H), 7.47-7.56 (m, 2 H), 7.80-7.91 (m, 3 H), 8.17 (d, J=5.5 Hz, 1 H), 8.25 (s, 1 H).

Sources & evidence

ORD record
ord-85ae51ac3cba401189a9ea1d519f89dd
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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