2-Methylimidazoline → HCID 59553146, compound

HRID 1171351Notes

Reaction equation

HRID 1171351 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH3:38][C:39]1[NH:40][CH2:41][CH2:42][N:43]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:43]3[CH2:42][CH2:41][N:40]=[C:39]3[CH3:38])[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 107982-MethylimidazolineHCID 667379693-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide

Product 1

HCID 59553146HCID 59553146, compound

Procedure

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 2-methyl-4,5-dihydro-1H-imidazole according to conditions described in general procedure C. 1H NMR (400 MHz, CDCl3) δ 1.63-1.70 (m, 9 H), 3.29 (t, J=5.5 Hz, 4H), 3.67 (t, J=8.8 Hz, 2 H), 3.83 (t, J=8.8 Hz, 2 H), 6.25-6.53 (m, 1 H), 6.77 (d, J=11.7 Hz, 1 H), 6.99 (d, J=8.0 Hz, 1 H), 7.25-7.31 (m, 2 H), 7.49-7.60 (m, 2 H), 7.88-7.93 (m, 2 H), 8.01 (d, J=8.0 Hz, 1 H), 8.17 (s, 1 H), 8.34-8.36 (m, 1 H).

Sources & evidence

ORD record
ord-8807fd41bb0d429d800bd2c339ccd5ca
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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