Cyclopentylamine → HCID 59553369, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-5-(4-methylpiperidin-1-yl)-N-(4-{[2-(methylthio)pyrimidin-4-yl]oxy}-1-naphthyl)benzamide (0.2 mmol) and cyclopentylamine (10 mmol) according to conditions described in Step 4 of Example 3 and general procedure C. A yellow solid (13 mg); Mp: 88-90° C.; 1H NMR (300 MHz, CDCl3) δ 0.98 (d, J=6.6 Hz, 3H), 1.23-1.87 (m, 13H), 2.77-2.85 (m, 2H), 3.76 (d, J=12.3 Hz, 2H), 4.08-4.15 (m, 1H), 5.15 (bs, 1H), 6.04 (s, 1H), 6.76 (d, J=12.3 Hz, 1H), 6.98 (d, J=8.4 Hz, 1H), 7.26-7.30 (m, 2H), 7.49-7.55 (m, 2H), 7.87-7.97 (m, 3H), 8.07-8.11 (m, 1H), 8.20 (s, 1H); MS 540 (M+1).

Provenance & Evidence