HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxyethyl)-2-pyrrolidinone → 3-Fluoro-5-piperidin-1-yl-N-[4-(pyridin-4-ylmethoxy)-1-naphthyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxyethyl)-2-pyrrolidinone | HCID 76980 | — |
| Reactant | tert-Butyl (4-hydroxynaphthalen-1-yl)carbamate | HCID 10923237 | — |
| Reactant | 3-Fluoro-5-piperidinylbenzoic acid | HCID 59553180 | — |
| Product | 3-Fluoro-5-piperidin-1-yl-N-[4-(pyridin-4-ylmethoxy)-1-naphthyl]benzamide | HCID 59553286 | — |
Reaction Steps
Compound is prepared from tert-butyl (4-hydroxy-1-naphthyl)carbamate, 3-fluoro-5-piperidin-1-yl-benzoic acid and 1-(2-hydroxy-ethyl)-pyrrolidin-2-one according to conditions described in general procedure D. A pink solid is produced (38 mg). Mp: 69-71° C.; 1H NMR (300 MHz, DMSO-d6) δ 1.58 (s, 6H), 3.28 (s, 4H), 5.42 (s, 2H), 6.95 (d, J=8.4 Hz, 1H), 7.06 (d, J=8.1Hz, 1H), 7.15 (d, J=6.9 Hz, 1H), 7.44 (s, 1H), 7.55-7.60 (m, 4H), 7.85-7.92 (m, 1H), 8.30-8.38 (m, 1H), 8.60-8.63 (m, 1H), 10.26 (s, 1H); MS 456 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07829560B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-aa75914666b045e7a55a3bf6d4e827eb |
| Source note | uspto-grants-2010_11 |