(2,5-Dimethylphenyl)boronic acid → HCID 59553381, compound

HRID 1171386Notes

Reaction equation

HRID 1171386 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][CH:29]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[CH:10][CH:9]=1)=[O:6].[CH3:30][C:31]1[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][C:32]=1B(O)O>>[N:21]1([CH2:20][CH2:19][O:18][C:11]2[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]([NH:7][C:5]([C:4]3[CH:3]=[C:2]([C:32]4[CH:33]=[C:34]([CH3:37])[CH:35]=[CH:36][C:31]=4[CH3:30])[CH:29]=[CH:28][CH:27]=3)=[O:6])=[CH:9][CH:10]=2)[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 2734347(2,5-Dimethylphenyl)boronic acidHCID 595531183-bromo-N-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-benzamide

Product 1

HCID 59553381HCID 59553381, compound

Procedure

Compound is prepared from 3-bromo-N-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-benzamide and 2,5-dimethylphenyl boronic acid according to conditions described in general procedure K. 1H NMR 300 MHz (CDCl3) δ 8.3 (d, 1H), 7.4-8.05 (m, 9H), 7.2 (d, 1H), 7.1 (d, 2H), 6.8 (d, 1H), 4.3 (t, 2H), 3.75 (m, 4H), 3.0 (t, 2H), 2.7 (m, 4H), 2.4 (s, 3H), 2.3 (s, 3H).

Sources & evidence

ORD record
ord-36826223988f4e91bc9341877c729ec9
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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