Hexylamine → 2-(4-{4-[5-(4-tert-Butylphenyl)-4-methyl-4H-[1,2,4]-triazol-3-ylsulfanyl]-2-heptyloxybenzyl amino}phenyl)-N-hexylacetamide

Participants

Reaction Steps

A solution of (4-{4-[5-(4-tert-butylphenyl)-4-methyl-4H-[1,2,4]-triazol-3-ylsulfanyl]-2-heptyloxybenzyl amino}phenyl)acetic acid (0.3 g, 0.5 mmol), benzotriazol-1-ol (0.074 g, 0.55 mmol) in dimethylformamide (10 ml) is stirred for 20 minutes. n-Hexylamine (0.066 ml, 0.5 mmol) and (3-dimethylaminopropyl)ethylcarbodiimide (0.105 g, 0.55 mmol) are added and then the medium is stirred for 24 hours at room temperature. The addition of water causes the formation of a precipitate which is dried before being purified by chromatography on a silica column, eluted with a heptane/ethyl acetate (3/7) mixture. After evaporation of the solvents, 0.205 g (60%) of the expected compound is recovered.

Provenance & Evidence