Acetic Acid → HCID 23138601, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (E)-3-[(furan-2-yl)methylidene]-1-(triphenylmethyl)piperidin-4-ol (3.70 g) in dichloromethane (75 ml) was added acetic acid (10 ml) under ice-cooling, and the resulting mixture was stirred at 60° C. for 3 hours. After stirring, acetic acid (10 ml) was added to the reaction mixture, and the resulting mixture was furthermore stirred at 60° C. for 1.5 hours. The reaction mixture was evaporated in vacuo, and the residue was purified by chromatography on a silica gel column using a mixed solvent of methanol and dichloromethane (1:19 to 1:9) as the eluent to afford the title compound (2.81 g, yield: quantitative) as a pale brown solid.

Provenance & Evidence