HCID 23138620, compound → HCID 23139182, compound

Participants

Reaction Steps

To a solution of (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(ethoxycarbonylmethyl)-1H-pyrazol-5-yl]methylidene}-4-sulfanylpiperidine hydrochloride (70 mg) in 3N aqueous hydrochloric acid solution (15 ml), and the resulting mixture was stirred at 50° C. for 2.5 hours. The reaction mixture was concentrated in vacuo, and the residue was purified by a preparative HPLC [YMC-Pack ODS-A; YMC, mobile phase: 25 to 27% acetonitrile/water (0.02% aqueous hydrochloric acid solution)] to afford the title compound (50 mg, yield: 75%) as a pale yellow amorphous solid.

Provenance & Evidence