Trifluoroacetic acid → HCID 23139308, compound

Participants

Reaction Steps

To a solution of (E)-4-(acetylsulfanyl)-3-({1-[3-(ethoxycarbonyl)propyl]-1H-1,2,3-triazol-5-yl}methylidene)-1-(triphenylmethyl)piperidine (7.45 g) in dichloromethane (80 ml) was added trifluoroacetic acid (2.86 ml) with stirring at room temperature. After the resulting mixture was stirred at room temperature for one hour, solvents were removed under reduced pressure. The residue was purified by silica gel chromatography using dichloromethane and methanol (10:1) as the eluent to afford the title compound (5.39 g, including impurities) as an orange-coloured oil.

Provenance & Evidence