Hydrochloric Acid → HCID 86609434, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (Z)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(ethoxycarbonylmethyl)-1H-pyrazol-3-yl]methylidene}-4-sulfanylpiperidine hydrochloride (309 mg) was added 3N hydrochloric acid (10 ml), and the mixture was stirred at 60° C. for 1 hour. After the mixture was concentrated under reduced pressure, the residue was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N hydrochloric acid, 40/60, v/v) to afford the title compound (227 mg, yield: 67%) as a colourless crystalline solid.

Provenance & Evidence