Hydrochloric Acid → HCID 23138551, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 134, (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(methoxycarbonylmethyl)-1H-1,2,3-triazol-5-yl]methylidene}-4-sulfanylpiperidine hydrochloride (200 mg) was treated with hydrochloric acid and the residue obtained by concentration was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N hydrochloric acid, 25/75, v/v) to afford the title compound (174 mg, yield: 90%) as a colourless amorphous solid.

Provenance & Evidence