Trifluoroacetic acid → HCID 86609448, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 132-(f), (E)-4-(acetylsulfanyl)-3-{[1-(methoxycarbonylmethyl)-1H-1,2,4-triazol-3-yl]methylidene}-1-(triphenylmethyl)piperidine obtained in Example 166-(c) was treated with trifluoroacetic acid in dichloromethane and the crude product was purified by silica gel chromatography using dichloromethane and methanol (20:1 to 10:1) as an eluent to afford the title compound (860 mg, yield: 54%) as a yellow amorphous solid.

Provenance & Evidence