HCID 23138469, compound → HCID 23139003, compound

HRID 1171715Notes

Reaction equation

HRID 1171715 reaction equation
FC(F)(F)C(O)=O.[C:8]([S:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14]/[C:13]/1=[CH:18]\[C:19]1[CH:23]=[C:22]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:21]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[N:20]=1)(=[O:10])[CH3:9].Br[CH:38]([C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[F:50])[C:39]([CH:41]1[CH2:43][CH2:42]1)=[O:40]>>[C:8]([S:11][CH:12]1[CH2:17][CH2:16][N:15]([CH:38]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=2[F:50])[C:39]([CH:41]2[CH2:42][CH2:43]2)=[O:40])[CH2:14]/[C:13]/1=[CH:18]\[C:19]1[CH:23]=[C:22]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:21]([C:30]([O:32][C:33]([CH3:35])([CH3:34])[CH3:36])=[O:31])[N:20]=1)(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 23138469HCID 23138469, compoundHCID 234358712-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one

Product 1

HCID 23139003HCID 23139003, compoundYield 81%

Procedure

Following a procedure similar to that described in Example 132-(g), (E)-4-(acetylsulfanyl)-3-{[1-(t-butoxycarbonyl)-5-(ethoxycarbonylmethyl)-1H-pyrazol-3-yl]methylidene}piperidine hydrogen trifluoroacetate (1.23 g) was subjected to the reaction with 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone. The product was purified by silica gel chromatography to afford the title compound (1.11 g, yield: 81%) as a pale yellow amorphous solid.

Workup

  1. customThe product was purified by silica gel chromatography

Sources & evidence

ORD record
ord-1b8abbe2de964125a51328e36770d3ac
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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