Hydrochloric Acid → HCID 86609459, compound

Participants

Reaction Steps

(Z)-1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[2-(ethoxycarbonyl)ethyl]-1H-pyrazol-3-yl}methylidene)-4-sulfanylpiperidine (the free base described in Example 171, 158 mg) was treated with 3N hydrochloric acid (5 ml) at 50° C. for 2 hours. The mixture was concentrated under reduced pressure and the residue was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N hydrochloric acid, 35/65, v/v) to afford the title compound (156.6 mg, yield: 97%) as a colourless amorphous solid.

Provenance & Evidence