Triethylamine → HCID 87568165, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 132-(g), (E)-4-(acetylsulfanyl)-3-{[2-(t-butoxycarbonylamino)-1,3-thiazol-4-yl]methylidene}piperidine hydrogen trifluoroacetate (420 mg) was subjected to the reaction with 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (340 mg) and triethylamine (310 μl) in acetonitrile (5 ml). The product obtained by usual extraction was purified by silica gel chromatography (eluent: hexane/ethylacetate=2/1˜2/3) to afford (E)-4-(acetylsulfanyl)-3-{[2-(t-butoxycarbonylamino)-1,3-thiazol-4-yl]methylidene}-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]piperidine (230 mg) as a pale yellow amorphous solid.

Provenance & Evidence