Hydrochloric Acid → HCID 23138682, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 134, (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(ethoxycarbonylmethyl)-1H-imidazol-2-yl]methylidene}-4-sulfanylpiperidine hydrochloride (155.6 mg) was treated with 3N hydrochloric acid (5 ml) at 50° C. for 2.5 hours. After the reaction solution of was concentrated under reduced pressure, the residue was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N hydrochloric acid, 15/85, v/v) to afford the title compound (149.0 mg, yield: quantitative) as a colourless amorphous solid.

Provenance & Evidence