Acetic Anhydride → HCID 86609466, compound

Participants

Reaction Steps

To a solution of (E)-3-{[1-(carboxymethyl)-1H-imidazol-2-yl]methylidene}-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanylpiperidine hydrochloride (85.6 mg) in dichloromethane (4 ml) were added triethylamine (120 μl) and acetic anhydride (80 μl) at 0° C. After the mixture was stirred at room temperature for 3 hours, solvents were removed under reduced pressure and the residue was purified by silica gel chromatography using methanol and dichloromethane (5:95 to 25:75) as eluents to afford the free base of the title compound (57.7 mg, yield: 71%) as a colourless oil.

Provenance & Evidence