Hydrochloric Acid → HCID 86609472, compound

Participants

Reaction Conditions

Reaction Steps

Hydrogen chloride was passed through a solution of (4R)-(E)-4-(acetylsulfanyl)-1-[(1RS)-1-(2-fluorophenyl)-2-methoxy-2-oxoethyl]-3-({1-[2-(ethoxycarbonyl)ethyl]-1H-pyrazol-3-yl}methylidene)piperidine (223.8 mg) in methanol (6 ml) while stirring at 0° C. and the sealed mixture was stirred at room temperature for 7 hours. The solvent and excess hydrogen chloride were evaporated under reduced pressure and the residue was purified by silica gel chromatography using methanol and dichloromethane (3:97 to 15:85, v/v) as eluents to afford the title compound (213.9 mg, yield: 99%) as a colourless amorphous solid.

Provenance & Evidence